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Synfacts 2005(1): 0137-0137  
DOI: 10.1055/s-2005-916015
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Catalytic, Enantioselective, Conjugate Alkyne Addition

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
T. F. Knöpfel, P. Zarotti, T. Ichikawa, E. M. Carreira*
ETH Hönggerberg, Zürich, Switzerland
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Publikationsdatum:
21. September 2005 (online)

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Significance

This system represents one of the few asymmetric conjugate addition reactions of alkynes and has the advantage of proceeding in aqueous conditions. The use of Meldrum’s acid as the acceptor is crucial for this reaction. The products are useful compounds as precursors to important molecules of pharmacological activity.