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Synfacts 2005(3): 0325-0325  
DOI: 10.1055/s-2005-916131
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Diastereoselective Synthesis of 1,2,3,5-Tetrasubstituted Pyrrolidines

Contributor(s): Mark Lautens, Y. Eric Fang
C. A. Carson, M. A. Kerr*
University of Western Ontario, Canada
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Publikationsdatum:
22. November 2005 (online)

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Significance

Highly substituted pyrrolidines were synthesized via a Yb(III)-catalyzed three-component reaction in good to excellent yield. A broad range of functionalities were compatible under the mild reaction conditions. In general, the diastereoselectivity was good to excellent except when in situ generated imines were derived from anilines or some heteroaryl aldehydes.