Pneumologie 2005; 59(12): 879-889
DOI: 10.1055/s-2005-919071
Serie: Pleuraerkrankungen (8)
© Georg Thieme Verlag Stuttgart · New York

Das Management des Spontanpneumothorax

The Management of Spontaneous PneumothoraxJ.-M.  Tschopp1 , W.  Frank2 , M.  Noppen3
  • 1Walliser Klinik für Lungenkrankheiten, Crans-Montana/Schweiz
  • 2Dr. W. Frank, Caputh/Deutschland
  • 3Interventional Endoscopy Unit, Academic Hospital AZ VUB, Bruxelles/Belgium
Further Information

Publication History

Publication Date:
27 December 2005 (online)

Zusammenfassung

Das optimale Management des Spontanpneumothorax (SPTX) beinhaltet konservative wie interventionelle, internistische wie chirurgische Optionen, bleibt aber hinsichtlich Akutbehandlung und Präventivstrategien wegen unzulänglicher Datenlage z. T. umstritten. Nach aktuellen Konsensusempfehlungen kann beim gering ausgedehnten und asymptomatischen Pneumothorax die Spontanresorption abgewartet werden. Ausgedehnte und symptomatische Pneumothoraxes können zu etwa 2/3 mit einer einfachen Aspiration oder englumigen Kathetern (< 16 F) erfolgreich behandelt werden. Die höchste Erfolgsquote bieten mit bis zu 96 % weitlumige Drainagen (> 20 F), die beim Versagen der einfachen Absaugung und bei Patienten mit sekundärem SPTX insbesondere im fortgeschrittenen Lebensalter bereits primär zu empfehlen sind - am besten in Verbindung mit der Thorakoskopie (Pleuroskopie). Eine Präventivtherapie ist spätestens beim 1. Rezidiv und primär beim Nachweis prädisponierender pleuropulmonaler Veränderungen wie beim sekundären PTX indiziert. Die derzeitige Datenlage erlaubt bezogen auf die Effektivität als primärer Endpunkt keine klare Präferenz zwischen einer internistischen Talkpoudrage und chirurgischen Strategien (üblicherweise VATS-gestützte partielle Pleurektomie ± Bullaablation bzw. Parenchymresektion). Die Therapieentscheidung bleibt daher ermessensabhängig. Die internistische thorakoskopische Talkpleurodese ist jedoch als hocheffektiv und sicher in der Prävention von Rezidiven anzusehen. Hierfür sprechen auch die niedrigen Kosten, die praktisch denen einer konservativen Behandlung mittels weitlumiger Pleuradrainage entsprechen.

Abstract

The optimum management of spontaneous pneumothorax (SPTX) includes medical and surgical approaches but remains somewhat controversial due to inconclusive data background both in the treatment of the acute episode and preventive strategies. Current consensus recommendations suggest, that small and asymptomatic pneumothoraces can be managed conservatively by observation. Large and symptomatic pneumothoraces will respond to simple aspiration or small size catheter (< 16 F) insertion in about 2/3 of cases. Otherwise, and in secondary SPTX, particularly in the elderly patient, large size (> 20 F) chest drainage, optimally combined with thoracoscopy (pleuroscopy), is the treatment of choice allowing success rates up to 96 %. Preventive strategies are indicated after the first recurrence and when predisposing pleuropulmonary lesions as in secondary SPTX are evident. With efficacy as a primary endpoint, currently available data do not provide clear evidence-based preference criteria between medical thoracoscopic talc pleurodesis and surgical strategies (usually VATS-based partial pleurectomy ± parenchymal resection). Therefore selection of the appropriate procedure remains influenced by expert opinion. However simple talc poudrage under medical thoracoscopy has been shown to be highly effective, safe and cheap at a cost level virtually not exceeding that of large size chest drainage.

Literatur

  • 1 Light R W. Management of spontaneous pneumothorax.  Am Rev Respir Dis. 1992;  148 245-248
  • 2 Miller A C, Harvey J E, BTS oboSoCC. Guidelines for the management of spontaneous pneumothorax.  BMJ. 1993;  307 114-116
  • 3 Henry M, Arnold T, Harvey J. BTS guidelines for the management of spontaneous pneumothorax.  Thorax. 2003;  58 (Supplement) 39-52
  • 4 Gupta D, Hansell A, Nichols T. et al . Epidemiology of pneumothorax in England.  Thorax. 2000;  55 666-671
  • 5 Melton L J, Hepper N CG, Offord K P. Incidence of spontaneous pneumothorax in Olmsted County, Minnesora: 1950 - 1974.  Am Rev Respir Dis. 1979;  29 1379-1382
  • 6 Bense L, Eklund G, Wiman L G. Smoking and the increased risk of contracting spontaneous pneumothorax.  Chest. 1987;  92 1009-1012
  • 7 Bense L, Wiman L G, Hedenstierna G. Onset of symptoms in spontaneous pneumothorax: correlations to physical activity.  Eur J Respir Dis. 1987;  71 181-186 (III)
  • 8 Noppen M, Verbanck S, Harvey J. et al . Music: a new cause of primary spontaneous pneumothorax.  Thorax. 2004;  59 772-724
  • 9 Jansveld C A, Dijkman J H. Primary spontaneous pneumothorax and smoking.  BMJ. 1975;  4 559-560
  • 10 Schramel F M, Golding R P, Haakman C D. et al . Expiratory chest radiographs do not improve visibility of small apical pneumothoraces by enhanced contrast.  Eur J Respir Dis. 1996;  9 406-409
  • 11 Glazer H, Anderson D J, Wilson B S. et al . Pneumothorax: appearances on lateral chest radiographs.  Radiology. 1989;  173 707-711
  • 12 Bourgoin P, Cousineau G, Lemire P. et al . Computed tomography used to exclude pneumothorax in bullous lung disease.  J Can Ass Radiol. 1985;  36 341-342
  • 13 Sattler A. Zur Behandlung der Spontanpneumothorax mit besonderer Berücksichtigung der Thorakoskopie.  Beitr Klin Tuberk. 1937;  89 394-408
  • 14 Mitlehner W, Friedrich M, Dissmann W. Value of computer tomography in the detection of bullae and blebs in patients with primary spontaneous pneumothorax.  Respiration. 1992;  59 221-227
  • 15 Lesur O, Delorme N, Fromaget J M. et al . Computed tomography in the etiologic assessment of idiopathic spontaneous pneumothorax.  Chest. 1990;  98 341-347
  • 16 Baronofsky I D, Warden H G, Kaufmann J L. et al . Bilateral therapy for unilateral spontaneous pneumothorax.  J Thorac Surg. 1957;  34 310-322
  • 17 Ikeda M, Uno A, Yamane Y. et al . Median sternotomy with bilateral bullous resection for unilateral spontaneous pneumothorax, with special reference to operative indications.  J Thorax Cardiovasc Surg. 1988;  96 615-620
  • 18 Radomsky J, Becker H P, Hartel W. Pleuroporosität beim idiopatischen Spontanpneumothorax.  Pneumologie. 1989;  43 250-253
  • 19 Ohata M, Suzuki H. Pathogenesis of spontaneous pneumothorax: with special reference to the ultrastructure of emphysematous bullae.  Chest. 1980;  77 771-776
  • 20 Janssen J P, Schramel F MNH, Sutedja T G. et al . Videothoracoscopic appearance of first and recurrent pneumothorax.  Chest. 1995;  108 330-334
  • 21 Bense L, Lewander R, Eklund G. et al . Nonsmoking, non-alpha-1-antitrypsin deficiency-induced emphysema in non-smokers with healed spontaneous pneumothorax, identified by computed tomography of the lungs.  Chest. 1993;  103 433-438
  • 22 Schramel F MNH, Meyer C LM, Postmus P E. Inflammation as cause of spontaneous and emphysematous-like changes: results of bronchoalveolar lavage.  Eur Respir J. 1995;  19 397s
  • 23 Schramel F MNH. Current aspects of spontaneous pneumothorax.  Eur Respir J. 1997;  10 1372-1379
  • 24 Sahn S A, Heffner J E. Spontaneous pneumothorax.  N Engl J Med. 2000;  342 868-874
  • 25 Baumann M H. Do blebs cause primary spontaneous pneumothorax? pro: blebs do cause primary spontaneous pneumothorax.  J Bronchol. 2002;  9 313-18
  • 26 Noppen M. Do blebs cause primary spontaneous pneumothorax? Con: Blebs do not cause primary spontaneous pneumothorax.  J Bronchol. 2002;  9 319-23
  • 27 Horio H, Nomori H, Kobayaski R. et al . Impact of additional pleurodesis in video-assisted thoracoscopic bullectomy for primary spontaneous pneumothorax.  Surg Endosc. 2002;  16 630-634
  • 28 Loubani M, Lynch V. Video-assisted thoracoscopic bullectomy and acromycin pleurodesis: an effective treatment for spontaneous pneumothorax.  Resp Med. 2000;  94 888-890
  • 29 Noppen M, Baumann M H. Pathogenesis and treatment of primary spontaneous pneumothorax: an overview.  Respiration. 2003;  70 431-438
  • 30 Hatz R A, Kaps M F, Meimarakis G. et al . Long-term results after video-assisted thoracoscopic surgery for wedge resection without pleurodesis or pleurectomy.  Eur J Cardio-thorac Surg. 2000;  10 656-659
  • 31 Dines D E, Clagett O T, Payne W S. Spontaneous pneumothorax in emphysema.  Mayo Clin Proc. 1970;  45 481-487
  • 32 Tanaka F, Itoh M, Esaki H. et al . Secondary spontaneous pneumothorax.  Ann Thorac Surg. 1993;  55 372-376
  • 33 Tunon-de-Lara J M, Constans J, Vincent M P. et al . Spontaneous pneumothorax associated with Pneumocystis carinii pneumonia.  Chest. 1992;  101 1177-1178
  • 34 Light R W, O'hara V S, Moritz T E. et al . Intrapleural tetracycline for the prevention of recurrent spontaneous pneumothorax: results of a Department of Veteran Affairs cooperative study.  JAMA. 1990;  264 2224-2230
  • 35 Lippert H L, Lund O, Blegvad S. et al . Independent risk factors for cumulative recurrence rate after first spontaneous pneumothorax.  Eur Respir J. 1991;  4 324-331
  • 36 British Thoracic Society Research Committee . Comparison of simple aspiration with intercostal drainage in the management of spontaneous pneumothorax.  Thorax. 1993;  48 430-431
  • 37 Edenborough F B, Hussain I, Stableforth D E. Use of a Heimlich flutter valve for pneumothorax in cystic fibrosis.  Thorax. 1994;  49 1178-1179
  • 38 Baumann M H, Strange C. The clinician's perspective on pneumothorax management.  Chest. 1997;  112 822-828
  • 39 Janssen J P, Cuesta M A, Postmus P E. Behandeling van spontane pneumothorax: enquete onder Nederlandse longartsen.  Ned Tijdschr Geneesk. 1994;  138 661-664
  • 40 Kinasewitz G T. Pneumothorax.  Sem Respir Crit Care Med. 1995;  16 (4) 293-302
  • 41 Baumann M H, Strange C, Heffner J E. et al . Management of spontaneous pneumothorax. An American College of Chest Physicians Delphi Consensus Statement.  Chest. 2001;  119 590-602
  • 42 Davies R JO, Gleeson F V, Ali N. et al . BTS guidelines for the management of pleural disease.  Thorax. 2003;  58 (Suppl. II) ii39-ii52
  • 43 Archer G J, Hamilton A AD, Upadhyag R. et al . Results of simple aspiration of pneumothoraces.  Brit J Dis Chest. 1985;  79 177-182
  • 44 Spencer-Jones J. A place for aspiration in the treatment of spontaneous pneumothorax.  Thorax. 1985;  40 66-67
  • 45 Harvey J. Simple aspiration vs. intercostal tube drainage for spontaneous pneumothorax in patients with normal lungs.  BMI. 1994;  309 1338-1339
  • 46 Ng A WK, Chan K W, Lee S K. Simple aspiration of pneumothorax.  Singapore Med J. 1994;  35 50-52
  • 47 Andrivet P, Djedaim K, Teboul J L. et al . Spontaneous pneumothorax, comparison of thoracic drainage vs. immediate or delayed needle aspiration.  Chest. 1995;  108 335-340
  • 48 Dines D E, Claget O TI, Payne W S. Spontaneous pneumothorax in emphysema.  Mayo Clin Proc. 1970;  45 481-487
  • 49 Noppen M, Alexander P, Driesen P. et al . Manual aspiration versus chest tube drainage in first episodes of primary spontaneous pneumothorax. A multicenter, prospective, randomized pilot study.  Am J Respir Crit Care Med. 2002;  165 1240-1244
  • 50 Baumann M H, Strange C H. Treatment of spontaneous pneumothorax. A more aggressive approach?.  Chest. 1997;  112 789-804
  • 51 So S Y, Yu D Y. Catheter drainage of spontaneous pneumothorax: suction or no suction, early or late removal.  Thorax. 1982;  38 46-48
  • 52 Röggla M, Wagner A, Brunner C. et al . The management of pneumothorax with the thoracic vent versus conventional intercostal tube drainage.  Wien Klin Wochschr. 1996;  108 330-333
  • 53 Devenand A, Koh M S, Ong T H. et al . Simple aspiration versus chest tube insertion in the management of primary spontaneous pneumothorax: a systematic review.  Respiratory Medicine. 2004;  98 579-590
  • 54 Noppen M, Stratakos G, Verbanck S. et al . Fluorescein-enhanced autofluorescence thoracoscopy in primary spontaneous pneumothorax.  Am J Respir Crit Care Med. 2004;  170 680-682
  • 55 Boutin C, Astoul P, Rey F. et al . Thoracoscopy in the diagnosis of spontaneous pneumothorax.  Clin Chest Med. 1995;  16/3 497-503
  • 56 Takeno Y. Thoracoscopic treatment of spontaneous pneumothorax.  Ann Thorac Surg. 1993;  56 688-90
  • 57 Loddenkemper R, Boutin C. Thoracoscopy: present diagnostic and therapeutic indications.  Eur Respir J. 1993;  5 1544-1555
  • 58 Frank W. Pneumothorax: Akutversorgung und Techniken der Pleurodese.  Atemw.-Lungenkrkh. 1998;  24/10 452-460
  • 59 Vanderschueren R G. The role of thoracoscopy in the evaluation and management of pneumothorax.  Lung. 1990;  (Suppl.) 1122-1125
  • 60 Sadikot R T, Greene T, Meadows K. et al . Recurrence of primary spontaneous pneumothorax.  Thorax. 1997;  52 805-809
  • 61 Bresticker M A, Oba J, LoCicero J. et al . Optimal pleurodesis: a comparison study.  Ann Thorac Surg. 1993;  55 364-367
  • 62 Lange P, Mortensen J, Groth S. Lung function 22 - 35 years after treatment of idiopathic spontaneous pneumothorax with talc poudrage or simple drainage.  Thorax. 1988;  43 559-561
  • 63 el Khawand C, Marchandise F X, Mayne A. et al . Spontaneous pneumothorax. Results of pleural talc therapy using thoracoscopy.  Rev Mal Respir. 1995;  12 (3) 275-281
  • 64 Light R W. Pro/Con editorials. Talc should not be used for pleurodesis.  Am J Respir Crit Care Med. 2000;  162 2024-2026
  • 65 Sahn S A. Pro/Con editorials. Talc should be used for pleurodesis.  Am J Respir Crit Care Med. 2000;  162 2023-2024
  • 66 Werebe E C, Pazetti R, Milanez de Campos J R. et al . Systemic distribution of talc after intrapleural administration in rats.  Chest. 1999;  115 190-193
  • 67 Fraticelli A, Robaglia-Schlupp A, Riera H. et al . Distribution of calibrated talc after intrapleural administration: an experimental study in rats.  Chest. 2002;  122 1737-1741
  • 68 Janssen J P, Noppen M, Astoul P. et al .persönliche Mitteilung. 
  • 69 Tschopp J M, Boutin C, Astoul P. et al . Talcage by medical thoracoscopy for primary spontaneous pneumothorax is more cost-effective than drainage: a randomised study.  Eur Respir J. 2002;  20 1003-1009
  • 70 Alfageme I, Moreno L, Huertas C. et al . Spontaneous pneumothorax: long term results with tetracycline pleurodesis.  Chest. 1994;  106 347-350
  • 71 Passlick B, Born C, Thetter O. Ergebnisse der minimal invasiven Chirurgie (MIC) bei der operativen behandlung des rezidivierenden oder persistierenden primären Spontanpneumothorax.  Pneumologie. 1997;  51 1135-1139
  • 72 Inderbitzi R GC, Furrer M, Striffeler H. et al . Thoracoscopic pleurectomy for treatment of complicated spontaneous pneumothorax.  J Thorac Cardiovasc Surg. 1993;  105/1 84-88
  • 73 Waller D A, Forty J, Moritt G N. Video-assisted thoracoscopic surgery versus thoracotomy for spontaneous pneumothorax.  Ann Thorac Surg. 1994;  58 372-376
  • 74 Sekine Y, Miyato Y, Yamada H. et al . Video-assisted thoracoscopic surgery does not deteriorate postoperative pulmonary gas exchange in spontaneous pneumothorax patients.  Eur J Cardiothorac Surg. 1999;  16 48-53
  • 75 Bernard A, Belichard C, Goudet P. et al . Pneumothorax spontanée. Comparaison de la thoracoscopie et de la thoracotomie.  Rev Mal Resp. 1993;  10 433-436
  • 76 Yim A P, Liu H P. Video assisted thoracoscopic management of primary spontaneous pneumothorax.  Surg Laparosc Endosc. 1997;  7 236-240
  • 77 Liu H P, Chang C H, Lin P J. et al . Thoracoscopic loop ligation of parenchymal blebs and bullae.  J Thorac Cardiovasc Surg. 1997;  113 50-54
  • 78 Kim K H, Kim H K, Jan J Y. et al . Transaxillary minithoracotomy versus video assisted thoracic surgery for spontaneous pneumothorax.  Ann Thorax Surg. 1996;  61 1510-1512
  • 79 Naunheim K S, Mack M J, Hazelrigg S R. et al . Safety and efficacy of video-assisted thoracic surgical techniques for the treatment of spontaneous pneumothorax.  J Thorac Cardiovasc Surg. 1995;  109 1198-1204
  • 80 Khalife J, Avtan L, Feito B. et al . Traitement des pneumothorax spontanés en vidéo-chirurgie: 32 observations.  Chirurgie. 1992;  118 648-651
  • 81 Suter M, Berner M, Vandoni R. et al . Traitement par thoracoscopie du pneumothorax récidivant.  Helv Chir Acta. 1994;  60 465-470
  • 82 Mouroux J, Benchimol D, Bernard J L. et al . Traitement chirurgical du pneumothorax par vidéo-thoracoscopie.  Presse Med. 1992;  21 1079-1082
  • 83 Freixinet J, Canalis E, Rivas J J. et al . Surgical treatment of primary spontaneous pneumothorax with video-assisted thoracic surgery.  Eur Respir J. 1997;  10 409-411
  • 84 Tanaka F, Itoh M, Esaki H. et al . Secondary spontaneous pneumothorax.  Ann Thorac Surg. 1993;  55 372-376
  • 85 Harrison Jr. L H. In some cases - avoid talc pleurodesis.  Chest. 1995;  108 289
  • 86 Judson M A, Sahn S A. The pleural space and organ transplantation.  Am J Respir Crit Care Med. 1996;  153 1153-1165
  • 87 Schramel F MNH, Sutedja T G, Braber J CE. et al . Cost-effectiveness of video-assisted thoracoscopic surgery versus conservative treatment for first time or recurrent spontaneous pneumothorax.  Eur Respir J. 1996;  9 1821-1825
  • 88 Schramel F MNH. Treatment of spontaneous pneumothorax - an ongoing debate.  Eur Respir J. 1998;  11 514-515 (reply)
  • 89 LeChevallier B, Jehan A, Gallet E. et al . Le talcage pleural par thoracoscopie dans le pneumothorax du grand insuffisant respiratoire obstructif.  Rev Mal Resp. 1987;  3 215-217
  • 90 Lee P, Wee S Y, Wee Y P. et al . An audit of medical thoracoscopy and talc poudrage for pneumothorax prevention in advanced COPD.  Chest. 2004;  125 1315-1320
  • 91 Light R W. Pneumothorax. In: Pleural diseases, 5th edition. Baltimore: Williams &Wilkins 2002: 242-277
  • 92 Frank W, Loddenkemper R. Pleural disease: Pneumothorax and bronchopleural fistula. London: Arnold 2002: 229-234

Bereits publizierte Beiträge zu dieser Serie:

Dr. Wolfgang Frank

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14548 Caputh/Deutschland

Email: wolfgangfrank@gmx.net

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