Synfacts 2005(3): 0284-0284  
DOI: 10.1055/s-2005-921595
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Biomimetic Synthesis of Juliprosine and Juliprosopine

Contributor(s): Philip Kocienski, Thomas Snaddon
B. B. Snider*, B. J. Neubert
Brandeis University, USA
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Publikationsverlauf

Publikationsdatum:
22. November 2005 (online)

Significance

Juliprosine and Juliprosopine are 2,3-dihydro-1H-indolizidinium alkaloids with potential antifungal activity. Snider and co-workers have described the first syntheses of these molecules via a biomimetic Chichibabin pyridine synthesis, and they have established the relative stereochemistry of Juliprosopine.