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Synfacts 2005(3): 0275-0275
DOI: 10.1055/s-2005-921596
DOI: 10.1055/s-2005-921596
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of Latrunculin A
A. Fürstner*, L. Turet
Max-Planck-Institut für Kohlenforschung, Mülheim/Ruhr, Germany
Further Information
Publication History
Publication Date:
22 November 2005 (online)
Significance
Latrunculins are a family of 2-thiazolidinone-containing macrolides isolated from the red sea sponge Negombata magnifica. As well as exhibiting significant cytotoxic and antiviral activity, they display potent and selective binding of the actin cytoskeleton in eukaryotic cells.