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Synfacts 2005(3): 0277-0277  
DOI: 10.1055/s-2005-921598
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Mycalamide A

Contributor(s): Philip Kocienski
J.-H. Sohn, N. Waizumi, H. M. Zhong, V. H. Rawal*
University of Chicago, USA
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

Mycalamide is isolated from a New Zealand sponge of the genus Mycale. It is a potent inhibitor of protein synthesis and it is an immunosuppressant more potent than FK-506 or cyclo­sporin A.