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Synfacts 2005(3): 0273-0273  
DOI: 10.1055/s-2005-921602
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Salinosporamide A

Contributor(s): Philip Kocienski, Fiona Black
A. Endo, S. J. Danishefsky*
Columbia University, New York, USA
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Publikationsdatum:
22. November 2005 (online)

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Significance

Salinosporamide A is a metabolite of the recently discovered Salinospora strain of bacteria. The high in vitro cytotoxicity (IC50 approx. 10 nm) of salinosporamide A makes it an attractive synthetic target with the mode of action believed to be inhibition of the 20S proteosome.