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Synfacts 2005(3): 0330-0330  
DOI: 10.1055/s-2005-921627
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Enantio- and Diastereoselective Tandem Preparation of Cyclopropyl Alcohols

Contributor(s): Paul Knochel, Andrei Gavryushin
H. Y. Kim, A. E. Lurain, P. García-García, P. J. Carroll, P. J. Walsh*
University of Pennsylvania, USA
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

This method offers a simple route for the enantioselective preparation of cyclopropyl carbinols, based on a single chiral catalyst. It allows to control up to four stereocenters in the molecule, applying highly diastereoselective transformations. The whole process is performed in a one-pot sequence.