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Synfacts 2005(3): 0336-0336  
DOI: 10.1055/s-2005-921631
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Alkylation of Aldehydes with Trialkylboranes

Contributor(s): Paul Knochel, Andrei Gavryushin
K. Hirano, H. Yorimitsu*, K. Oshima*
Kyoto University, Japan
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Publication History

Publication Date:
22 November 2005 (online)

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Significance

This is a first example of the addition of alkylboranes to aldehydes, catalyzed by transition metals. The process can be performed in a one-pot reaction starting from alkene and 9-BBN. An interesting promoting effect of some alkenes on this coupling reaction was demonstrated.