Vanadium-Catalyzed Pinacol Coupling of Benzaldehydes in Water

X. Xu; T. Hirao

doi:10.1055/s-2005-921634

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Synfacts 2005(3): 0340-0340
DOI: 10.1055/s-2005-921634

Metal-Mediated Synthesis

Vanadium-Catalyzed Pinacol Coupling of Benzaldehydes in Water

Contributor(s): Paul Knochel, Andrei Gavryushin
X. Xu, T. Hirao*
Osaka University, Japan

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Publication History

Publication Date:
22 November 2005 (online)

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Significance

A convenient and simple procedure for the preparation of dihydrobenzoins from benzaldehydes, employing VCl₃ as a catalyst and Al powder as a reducing agent is described. The reaction is performed in water, which facilitates the product isolation and minimizes the waste problems.