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Synfacts 2006(3): 0243-0243
DOI: 10.1055/s-2006-231949
DOI: 10.1055/s-2006-231949
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Dual Catalytic Decarbonylation/Asymmetric Pauson-Khand-Type Reaction
F. Y. Kwong*, H. W. Lee, L. Qiu, W. H. Lam, Y.-M. Li, H. L. Kwong, A. S. C. Chan*
Hong Kong Polytechnic University, State Key Laboratory of Chinese Medicine and Molecular Pharmacology, Shenzhen; City University of Hong Kong, P. R. China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. Februar 2006 (online)
Significance
The Pauson-Khand (P-K) reaction has been well developed over the past 30 years, and generally requires the use of a toxic CO(g) atmosphere. The recent resurgence of catalytic decarbonylation has enabled the use of aldehydes as a safe carbonyl source for enantioselective P-K-type reactions. In the presence of [Rh(COD)Cl]2, (S)-BisbenzodioxanPhos, cinnamaldehyde and tert-amyl alcohol as solvent, a variety of enynes were enantioselectively converted into bicyclic enones with good yields and enantioselectivities.