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Synfacts 2006(3): 0280-0280  
DOI: 10.1055/s-2006-931990
Bioorganic Chemistry and Organocatalysis
© Georg Thieme Verlag Stuttgart · New York

Organocatalytic Direct Asymmetric Aldol Reactions in Water

Contributor(s): Benjamin List, Sebastian Hoffmann
N. Mase, Y. Nakai, N. Ohara, H. Yoda, K. Takabe*, F. Tanaka, C. F. Barbas III*
Shizuoka University, Hamamatsu, Japan and The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
21 February 2006 (online)

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Significance

An asymmetric aldol reaction of aliphatic donors with aromatic aldehydes catalyzed by a proline-derived diamine-acid bifunctional catalyst is described. The reactions can be run in water and the products were obtained in good yields, diastereoselectivities, and up to 99% enantioselectivity.