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Synfacts 2006(3): 0267-0267
DOI: 10.1055/s-2006-932008
DOI: 10.1055/s-2006-932008
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Ni-Catalyzed Cross-Coupling Reaction under Ni/Mg Bimetallic Cooperation
N. Yoshikai, H. Mashima, E. Nakamura*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
21 February 2006 (online)
Significance
The C(sp2)-C(sp2) cross-coupling reaction is one of the most important methods in current organic chemistry. Numerous transition-metal catalysts were developed and tested for this process. The use of Ni catalysts is especially advantageous, due to its lower price and ease of removal. This work represents a breakthrough in the field of cross-coupling reactions, as it describes the use of a bimetallic cooperative catalysis. Impressively, even electron-rich aryl fluorides can be easily converted in the reaction, and in case of activated substrates only 0.05 mol% of Ni catalyst is sufficient for an excellent product yield.