Ni-Catalyzed Cross-Coupling Reaction under Ni/Mg Bimetallic Cooperation

Significance

The C(sp²)-C(sp²) cross-coupling reaction is one of the most important methods in current organic chemistry. Numerous transition-metal catalysts were developed and tested for this process. The use of Ni catalysts is especially advantageous, due to its lower price and ease of removal. This work represents a breakthrough in the field of cross-coupling reactions, as it describes the use of a bimetallic cooperative catalysis. Impressively, even electron-rich aryl fluorides can be easily converted in the reaction, and in case of ­activated substrates only 0.05 mol% of Ni catalyst is sufficient for an excellent product yield.