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Synfacts 2006(5): 0424-0424  
DOI: 10.1055/s-2006-934391
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Brazilin

Contributor(s): Philip Kocienski, Fiona Black
Y. Huang, J. Zhang, T. R. R. Pettus*
University of California at Santa Barbara, USA
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Publikationsdatum:
21. April 2006 (online)

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Significance

(+)-Brazilin is a micromolar telo­merase inhibitor and has the ability to nick DNA making it a potential anti-cancer agent. (+)-Brazilin and related natural products have been isolated from Brazil wood trees found in regions around the equator. A synthesis of (±)-brazilin is reported in nine steps and 8.5% yield.