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Synfacts 2006(7): 0643-0643
DOI: 10.1055/s-2006-941833
DOI: 10.1055/s-2006-941833
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (+)-Cylindramide A
A. C. Hart, A. J. Phillips*
University of Colorado, Boulder, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2006 (online)
Significance
(+)-Cylindramide is a tetramic acid-containing macrolactam isolated from the sponge Halichondria cylindrata that has cytotoxic and anti-microbial properties. Hart and Phillips use a tandem ring-opening ring-closing cross-metathesis reaction as the focal point of their total synthesis.