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Synfacts 2006(7): 0644-0644
DOI: 10.1055/s-2006-941836
DOI: 10.1055/s-2006-941836
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Bao Gong Teng A
Y. Zhang, L. S. Liebeskind*
Emory University, Atlanta, USA
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
Bao Gong Teng A is isolated from Erycibe obtusifolia, a herb used in traditional Chinese medicine for the treatment of glaucoma. The tropane ring system was created by a [5+2] cycloaddition of the enantiopure TpMo(CO)2(η3-pyridinyl) complex A in which the metal controls the diastereofacial selectivity of the cycloaddition.