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Synfacts 2006(7): 0698-0698
DOI: 10.1055/s-2006-941862
DOI: 10.1055/s-2006-941862
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Mn-Catalyzed Reformatsky Reaction with Ketones
P. G. Cozzi*
Università Di Bologna, Italy
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
The Reformatsky reaction is a very efficient C-C bond formation reaction due to the mildness of the zinc reagent used (high functional group tolerance) and the complete regioselectivity in the enolate formation (always at the α-halo carbonyl center). Cozzi describes a manganese-catalyzed enantioselective Reformatsky reaction with ketones using Me2Zn as the zinc source.