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Synfacts 2006(7): 0738-0738  
DOI: 10.1055/s-2006-941903
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Microwave-Assisted Microreactor for Suzuki and Heck Reactions

Contributor(s): Yasuhiro Uozumi, Yoichi M. A. Yamada
G. Shore, S. Morin, M. G. Organ*
York University, Toronto, Canada
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

A palladium thin film deposited onto an inner surface of a microcapillary was prepared by pyrolysis of Pd(OAc)2, and it was applied to microwave-assisted continuous-flow organic synthesis. The Pd film catalyzed the continuous-flow (10 µm/min) Suzuki-Miyaura reaction of aryl bromides with arylboronic acids inside the capillary under microwave irradiation to give the cross-coupling products in 73-97% yield (11 examples). The morphology and elementary composition of the Pd thin films were examined by SEM and EDX.