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Synfacts 2006(8): 0831-0831  
DOI: 10.1055/s-2006-942005
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

Mg-TiCl4-CH2Cl2 System for General Enamine Cyclopropanation

Contributor(s): Paul Knochel, Andrei Gavryushin
C.-C. Tsai, I.-L. Hsieh, T.-T. Cheng, P.-K. Tsai, K.-W. Lin, T.-H. Yan*
National Chung-Hsing University, Taiwan, P. R. of China
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Publication History

Publication Date:
21 July 2006 (online)

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Significance

This article describes further implications of the very convenient method of carbenoid generation, developed by the same authors (see: Synfacts 2006, 837). This is probably the most practical way for cyclopropanation of enamines, leading to substituted cyclopropylamines. The process is operationally simple and requires only inexpensive, safe and non-toxic starting materials. Using CD2Cl2, deuterated cyclo­propylamines were also prepared.