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Synfacts 2006(9): 0907-0907  
DOI: 10.1055/s-2006-942059
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

C 3-Symmetric Tripodal β-Hydroxy Amide Mediated Borane Reduction

Contributor(s): Mark Lautens, Yann Béthuel
T. Fang, J. Xu, D.-M. Du*
Peking University, P. R. of China
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Publikationsdatum:
23. August 2006 (online)

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Significance

The authors have recently described the convenient synthesis of C 3-symmetric tris(β-hydroxy amide) ligands (2 steps, 70-96% yield) for the Ti-mediated enantioselective alkynyl­ation of aldehydes (Org. Lett. 2005, 7, 2081-2084). In the present paper, a new ligand based on the same core structure is applied in the selective borane reduction of prochiral ketones.