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Synfacts 2006(9): 0941-0941
DOI: 10.1055/s-2006-949218
DOI: 10.1055/s-2006-949218
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Chiral Allenylzinc and Indium Reagents for Asymmetric Propargylation
J. A. Marshall*, P. Eidam, H. S. Eidam
University of Virginia, Charlottesville, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. August 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200609/lookinside/thumbnails/10.1055-s-2006-949218-1.jpg)
Significance
This article describes the further developments of the elegant and synthetically useful methodology designed earlier by the same group, which allows the enantioselective addition of a chiral C-4 synthon to an aldehyde. The authors designed a robust, practical synthesis of the required chiral precursor and described some new applications of their method. This protocol is an excellent alternative to the anti-aldol reaction, which should find a broad application in synthesis of natural products, especially polyketides.