Download PDF
Synfacts 2006(9): 0928-0928  
DOI: 10.1055/s-2006-949239
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Zinc-Catalyzed Enantioselective Hydrosilylation of Imines

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
B.-M. Park, S. Mun, J. Yun*
Sungkyunkwan University, Korea
Further Information

Publication History

Publication Date:
23 August 2006 (online)

    Permissions and Reprints

Significance

The authors report a nice example of hydrosilylation of imines using inexpensive polymethylhydrosiloxane. This reagent must be used in a mixed solvent system (THF-MeOH) to obtain good selectivity. The use of simple, modular diamines also makes this protocol attractive for future use. N-Diphenylphosphinyl imines were formed stereoselectively and afforded appropriate reactivity for the reduction.