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Synfacts 2006(9): 0924-0924
DOI: 10.1055/s-2006-949241
DOI: 10.1055/s-2006-949241
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Addition of Aldehyde-Derived Enecarbamates to α-Oxo Aldehydes
R. Matsubara, N. Kawai, S. Kobayashi*
The University of Tokyo, Japan
Further Information
Publication History
Publication Date:
23 August 2006 (online)
Significance
The aldol reaction with aldehyde-derived enecarbamates is a useful way to avoid self-condensation or unwanted side-products, which is often observed with simple aldehydes. These substrates are also more stable to air and water than are aldehydes. The intermediate polymer products proposed were transformed to monomeric products in the presence of scandium catalyst.