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Synfacts 2006(9): 0919-0919
DOI: 10.1055/s-2006-949272
DOI: 10.1055/s-2006-949272
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Catalytic Enantioselective Allylic Monofluoromethylation
T. Fukuzumi, N. Shibata*, M. Sugiura, H. Yasui, S. Nakamura, T. Toru*
Nagoya Institute of Technology, Japan
Further Information
Publication History
Publication Date:
23 August 2006 (online)

Significance
Fluorinated compounds are of great utility in medicinal and agricultural chemistry (see first book below) and the selective introduction of a fluorine atom in a molecule has become a useful approach in new drug design. In this respect, many different strategies have been reported over the last few years (see second book below). In the present paper, the authors report the first enantioselective allylic monofluoromethylation using fluorobis(phenylsulfonyl)methane and its application in the synthesis of biologically relevant compounds.