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Synfacts 2006(10): 1040-1040
DOI: 10.1055/s-2006-949278
DOI: 10.1055/s-2006-949278
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Ru(II)/Chiral Diphosphonite Asymmetric Keto Ester Hydrogenation
M. T. Reetz*, X. Li
Max-Planck-Institut für Kohlenforschung, Mühlheim/Ruhr, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
Significance
Using a Ru(II)/BINOL-derived diphosphonite catalyst system, several β-keto esters were enantioselectively hydrogenated to the corresponding β-hydroxy esters with excellent yields and ee values. The catalyst was also used for the dynamic kinetic resolution of a cyclic β-keto ester to yield a single diastereomer, but was unsuccessful in doing so for an acyclic case.