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Synfacts 2006(10): 1024-1024  
DOI: 10.1055/s-2006-949284
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Bulky Chiral Ligand for Rh-Catalyzed Carbenoid Reactions

Contributor(s): Mark Lautens, Frédéric Ménard
R. P. Reddy, G. H. Lee, H. M. L. Davies*
State University of New York, Buffalo, USA
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Publikationsdatum:
21. September 2006 (online)

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Significance

The chiral catalyst Rh2[(S)-DOSP]4 is usually the best catalyst for reactions with donor/acceptor carbenoids. However, the new Rh2[(S)-PTAD]4 complex was shown to be an excellent back-up catalyst for cases where Rh2[(S)-DOSP]4 did not achieve satisfactory enantioselectivity.