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Synfacts 2006(10): 1078-1078
DOI: 10.1055/s-2006-949296
DOI: 10.1055/s-2006-949296
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Silica-Supported Pd/Cu Catalysts for the Sonogashira Coupling
T. Posset, J. Blümel*
University of Heidelberg, Germany
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
Significance
The Sonogashira coupling by using PdCl2(PPh3)2/silica-supported Cu complex 3 was developed. The linker (EtO)3Si(CH2)3N(CH2PPh2)2 (1) was attached to the silica support to give immobilized bisphosphine 2. The silica-supported Cu complex 3 was prepared from the resulting immobilized ligand 2, Cu(MeCN)4BF4, and PPh3. The Sonogashira coupling of iodobenzene with phenylacetylene by using PdCl2(PPh3)2 and the silica-supported Cu complex 3 gave tolane in quantitative yield. This supported Cu catalyst was reused several times without loss of activity (1st-11th: >90% conversion).