Synthesis of Calyxin L

X. Tian; J. J. Jaber; S. D. Rychnovsky

doi:10.1055/s-2006-949315

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Synfacts 2006(10): 0978-0978
DOI: 10.1055/s-2006-949315

Synthesis of Natural Products and Potential Drugs

Synthesis of Calyxin L

Contributor(s): Philip Kocienski, John Cooksey
X. Tian, J. J. Jaber, S. D. Rychnovsky*
University of California, Irvine, USA

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Publication History

Publication Date:
21 September 2006 (online)

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Significance

The Calyxin family of natural products is isolated from Alpinia blepharocalyx seeds and its members exhibit potent antiproliferative activity. The Rychnovsky group prepared several of the calyxins using a tandem Prins/Friedel-Crafts cyclization reaction.