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Synfacts 2006(10): 1032-1032
DOI: 10.1055/s-2006-949325
DOI: 10.1055/s-2006-949325
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Rh and Ir[Bis(oxazolinyl)] Complexes: New Asymmetric Catalysts
J.-I. Ito, T. Shiomi, H. Nishiyama*
Nagoya University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
Significance
New 3,5-dimethyl-substituted PheBox ligands have been synthesized and their efficacy for asymmetric conjugate reduction and reductive aldol condensation was tested. The catalyst complex was prepared through C-H activation of the ligand to generate the Rh and Ir catalyst precursors. Exchange of the chloride to acetate with AgOAc gave the active species. The catalyst activity and selectivity for the Rh complex was on par with the previous unsubstituted PheBox system, but the Ir complex showed much lower reactivity and selectivity.