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Synfacts 2006(10): 0982-0982
DOI: 10.1055/s-2006-949326
DOI: 10.1055/s-2006-949326
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (-)-Cassine
C. Herdeis*, P. Küpper, S. Plé
Universität Würzburg, Germany
Further Information
Publication History
Publication Date:
21 September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949326-1.jpg)
Significance
(-)-Cassine, isolated from the leaves of Cassia excelsa, displays antimicrobial activity against Staphylococcus aureus. This route relies on a tandem Horner-Wadsworth-Emmons/1,3-dipolar cycloaddition cascade sequence that simultaneously appends the aliphatic side-chain and forms the trisubstituted piperidine ring.