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Synfacts 2006(10): 0981-0981  
DOI: 10.1055/s-2006-949334
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Cylindrospermopsin

Contributor(s): Philip Kocienski, Thomas Snaddon
R. E. Looper, M. T. C. Runnegar, R. M. Williams*
Colorado State University, Fort Collins and University of Southern California Medical Center, Los Angeles, USA
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Publication History

Publication Date:
21 September 2006 (online)

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Significance

Cylindrospermopsin is a potent hepatotoxin that disrupts the translation process of protein synthesis by an unknown mechanism. Williams and co-workers devised a synthetic route to cyclindrospermopsin that relies on intramolecular nitrone 1,3-dipolar cycloaddition and reductive guanidinylation reactions.