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Synfacts 2007(1): 0062-0062  
DOI: 10.1055/s-2006-955724
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ferrocenophane Diphosphine Ligands for Pd-Catalyzed Allylic Substitution

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
R. Šebesta*, A. Almassy, I. Císařová, . Toma
Comenius University, Bratislava, Slovakia and Charles University, Prague, Czech Republic
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Publication History

Publication Date:
15 December 2006 (online)

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Significance

This paper describes the development of new [5]ferrocenophane-type ligands. This type of ligand is closely related to the JosiPhos-type ligand, but contains a five-carbon linker. The chirality in the ligand is installed via an enantio­selective CBS reduction of the ketone precursor. The structure was confirmed by X-ray crystallography and the ligand succeeded in the Pd-catalyzed allylic substitution reaction giving 88% yield with 91% ee.