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Synfacts 2007(2): 0168-0168  
DOI: 10.1055/s-2006-955839
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Amination of Enecarbamates

Contributor(s): Hisashi Yamamoto, Joshua P. Abell
R. Matsubara, S. Kobayashi*
The University of Tokyo, Japan
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Publication History

Publication Date:
23 January 2007 (online)

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Significance

In spite of the fact that several methods for enantioselective amination of enecarbamates have been developed, these systems typically require relatively high catalyst loading and/or limited substrate scope. This paper is the first to demonstrate catalytic asymmetric amination of enecarbamates catalyzed by a chiral diamine-copper complex using azodicarboxylates.