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Synfacts 2007(3): 0241-0241  
DOI: 10.1055/s-2007-968189
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Strychnofoline

Contributor(s): Philip Kocienski
A. Lerchner, E. M. Carreira*
ETH Zürich, Switzerland
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Publikationsdatum:
20. Februar 2007 (online)

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Significance

Strychofoline is an oxindole alkaloid isolated from the leaves of Strychnos usambarensis. It inhibits mitosis in a number of cancer cell lines. Lerchner and Carreira use a ring expansion of the spiro[cyclopropane-1,3′-oxindole] E as the plinth for their construction of (±)-strychnofoline.