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Synfacts 2007(3): 0234-0234  
DOI: 10.1055/s-2007-968195
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Himgaline

Contributor(s): Philip Kocienski, Fiona Black
U. Shah, S. Chackalamannil*, A. K. Ganguly*, M. Chelliah, S. Kolotuchin, A. Buevich, A. McPhail
Schering-Plough Research Institute, Kenilworth, Stevens Institute of Technology, Hoboken and Duke University, Durham, USA
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Publication History

Publication Date:
20 February 2007 (online)

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Significance

(-)-Himgaline is an alkaloid isolated from the rare rainforest tree Galbulimima belgraveana. The first total synthesis of (-)-himgaline is completed in 32 steps from the previously reported aldehyde A (S. Chackalamannil et al.J. Med. Chem. 2005, 48, 5884-5887).