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Synfacts 2007(3): 0239-0239  
DOI: 10.1055/s-2007-968199
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Formal Synthesis of (-)-Balanol

Contributor(s): Philip Kocienski, Zofia Komsta
M. G. Unthank, N. Hussain, V. K. Aggarwal*
University of Bristol and GlaxoSmithkline, Tonbridge, UK
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Publikationsdatum:
20. Februar 2007 (online)

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Significance

Aggarwal and co-workers developed a method for the conversion of various amino aldehydes and ketones into the corresponding epoxide- and aziridine-fused heterocycles. This method was used for the construction of hexa­hydroazepine J, a key intermediate in a previous synthesis of the protein kinase C inhibitor (-)-balanol (D. Tanner et al. Tetrahedron 1997, 53, 4857-4868).