Download PDF
Synfacts 2007(4): 0354-0354  
DOI: 10.1055/s-2007-968282
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (-)-Amphidinolide E

Contributor(s): Philip Kocienski, Fiona Black
C. H. Kim, H. J. An, W. K. Shin, W. Yu, S. K. Woo, S. K. Jung, E. Lee*
Seoul National University, Korea
Further Information

Publication History

Publication Date:
23 March 2007 (online)

    Permissions and Reprints

Significance

(-)-Amphidinolide E, isolated from the dinoflagellate Amphidinium sp., shows cytotoxic activity against cancer cell lines in vitro. The 18-membered macrolide ring is formed using Kita’s lactonization conditions (J. Chem. Soc., Perkin Trans. 1 1993, 2999-3005). A radical cyclization is employed in the synthesis of the tetrahydrofuran ring.