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Synfacts 2007(4): 0343-0343  
DOI: 10.1055/s-2007-968289
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of N1999A2

Contributor(s): Philip Kocienski, Thomas Snaddon
N. Ji, H. O’Dowd, B. M. Rosen, A. G. Myers*
Harvard University, Cambridge, USA
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

N1999A2 is an enediyne antibiotic that damages DNA by radical means. Noteworthy in this synthesis is the deft use of mild organometallic processes and a carefully wrought protecting group strategy to accomplish construction of the very sensitive target.