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Synfacts 2007(4): 0449-0449
DOI: 10.1055/s-2007-968306
DOI: 10.1055/s-2007-968306
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Alumina-Supported CeCl3 ×7H2O/NaI Catalyst
N. Ahmed, J. E. van Lier*
Université de Sherbrooke, Canada
Further Information
Publication History
Publication Date:
23 March 2007 (online)
Significance
Alumina-supported CeCl3 ×7H2O-NaI catalyst for the cyclization of 2′-aminochalcones 1 giving 2,3-dihydroquinoline derivatives 2 was described. Thus, treatment of neutral alumina with CeCl3×7H2O and NaI in MeCN gave the alumina-supported CeCl3×7H2O-NaI. The intramolecular aza-Michael reaction of 2′-aminochalcones 1 was carried out in the presence of the alumina-supported CeCl3×7H2O-NaI at 70 °C under solvent-free conditions to give the corresponding 2-aryl-2,3-dihydroquinolin-4(1H)-ones 2 in 83-98% yield.