Ti(IV)-BINOL-Catalyzed Highly Concentrated Asymmetric Allylation of Ketones

Significance

Reactions under solvent-free and highly concentrated conditions possess high environmental and economical benefits, as they minimize the waste treatment problems. This publication describes a solvent-free modification of the method for enantioselective allylation of ketones, previously developed by the group of Walsh. In the absence of solvents, the catalyst loading can be reduced three-fold without the loss of enantio­selectivity. The overall method is quite simple, practical and offers tertiary homoallylic alcohols in excellent yields and enantioselectivities.