Download PDF
Synfacts 2007(4): 0410-0410  
DOI: 10.1055/s-2007-968382
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Copper-Diamino Oligothiophene Catalyzed Henry Reaction

Contributor(s): Mark Lautens, Yann Béthuel
M. Bandini*, F. Piccinelli, S. Tommasi, A. Umani-Ronchi*, C. Ventrici
Università di Bologna, Italy
Further Information

Publication History

Publication Date:
23 March 2007 (online)

    Permissions and Reprints

Significance

Recently, many groups have sought an efficient and practical asymmetric Henry reaction (C. Palomo, M. Oiarbide, A. Mielgo Angew. Chem. Int. Ed. 2004, 43, 5442-5444). In the present paper, the authors used their chiral copper-diamino oligothiophene catalyst system (Adv. Synth. Catal. 2005, 347, 1507-1512) to develop a highly selective nitroaldol condensation at moderate catalyst loadings.