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Synfacts 2007(4): 0410-0410  
DOI: 10.1055/s-2007-968382
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Copper-Diamino Oligothiophene Catalyzed Henry Reaction

Contributor(s): Mark Lautens, Yann Béthuel
M. Bandini*, F. Piccinelli, S. Tommasi, A. Umani-Ronchi*, C. Ventrici
Università di Bologna, Italy
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Publikationsdatum:
23. März 2007 (online)

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Significance

Recently, many groups have sought an efficient and practical asymmetric Henry reaction (C. Palomo, M. Oiarbide, A. Mielgo Angew. Chem. Int. Ed. 2004, 43, 5442-5444). In the present paper, the authors used their chiral copper-diamino oligothiophene catalyst system (Adv. Synth. Catal. 2005, 347, 1507-1512) to develop a highly selective nitroaldol condensation at moderate catalyst loadings.