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Synfacts 2007(4): 0398-0398  
DOI: 10.1055/s-2007-968384
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Chiral Bisimidazoline Ligands for Highly Enantioselective Henry Reaction

Contributor(s): Mark Lautens, Yann Béthuel
K. Ma, J. You*
Sichuan University, Chengdu, P. R. of China
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

In this paper, the authors developed a new synthesis of Beller’s bisimidazoline ligand (Org. Lett. 2005, 7, 3393-3396) that allows modified versions to be readily prepared. They tested several of these ligands in a copper-catalyzed enantioselective nitroaldol reaction and found an N-phenyl bisimidazoline that was particularly effective.