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Synfacts 2007(4): 0394-0394  
DOI: 10.1055/s-2007-968385
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Chiral Phosphane-Phosphites Ligand for the Synthesis of α-Acyloxy Phosphonates

Contributor(s): Mark Lautens, Yann Béthuel
M. Rubio, S. Vargas, A. Suárez, E. Álvarez, A. Pizzano*
Consejo Superior de Investigaciones CientÍficas and Universidad de Sevilla, Spain
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Publication History

Publication Date:
23 March 2007 (online)

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Significance

Since the first report by Takaya and co-workers on chiral phosphane-phosphite ligands (J. Am. Chem Soc. 1993 , 115, 7033-7034), significant efforts have been directed towards the development of new enantioselective transformations promoted by these ligands. In the present paper, the authors modify a ligand recently used in the hydrogenation of dimethyl itaconate (A. Suárez et al. Organometallics 2002, 21, 4611-4621) and apply it in the rhodium-catalyzed hydrogenation of enol ester phophonates.