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Synfacts 2007(5): 0488-0488  
DOI: 10.1055/s-2007-968411
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Cholestanofluorene

Contributor(s): Timothy M. Swager, Eric L. Dane
P. Debroy, R. Shukla, S. V. Lindeman, R. Rathore*
Marquette University, Milwaukee, USA
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Publikationsverlauf

Publikationsdatum:
24. April 2007 (online)

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Significance

The authors report an efficient route to a fluorene derivative with the 9,9′-positions functionalized with cholesterol’s carbon skeleton. Because attack of cholestanone with 2-biphenylmetal reagents was low-yielding, the authors chose to brominate and use a palladium-catalyzed Kumada coupling.