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Synfacts 2007(6): 0626-0626  
DOI: 10.1055/s-2007-968505
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Cu(I)-Thiophosphoramide-Catalyzed Cycloaddition of Azomethine Ylides

Contributor(s): Hisashi Yamamoto, Marina Naodovic
M. Shi*, J. W. Shi
East China University of Science and Technology and Shanghai Institute of Organic Chemistry, Shanghai, P. R. of China
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Publikationsdatum:
22. Mai 2007 (online)

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Significance

It has been reported previously by Shi (Synlett 2007, 19-30) that chiral diphenyl-thiophosphoramides, -selenophosphoramides and phosphoramides of various diamines are effective ligands for several catalytic, stereoselective C-C bond-forming reactions. In this report, the authors make a further investigation of the reactivity of these types of ligands in asymmetric transformations. Although only moderate enantioselectivities are observed, these are only the initial results. The thiophosphoramide-copper complex appears to have vast potential for other copper-catalyzed asymmetric reactions.