PDF herunterladen
Synfacts 2007(6): 0576-0576  
DOI: 10.1055/s-2007-968511
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (+)-Gliocladin C

Contributor(s): Philip Kocienski, Thomas Snaddon
L. E. Overman*, Y. Shin
University of California, Irvine, USA
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
22. Mai 2007 (online)

    Lizenzen und Reprints

Significance

(+)-Gliocladin C is a marine indole alkaloid that displays cytotoxic activity in leukemia assays. This synthesis, which relies on a Mukaiyama aldol reaction to install the difficult C3-indolyl stereocenter, established the absolute configuration of the natural product.