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Synfacts 2007(6): 0564-0564  
DOI: 10.1055/s-2007-968513
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Marinomycin A

Contributor(s): Philip Kocienski
K. C. Nicolaou*, A. L. Nold, R. R. Milburn, C. S. Schindler, K. P. Cole, J. Yamaguchi
The Scripps Research Institute and University of California, San diego, La Jolla, USA
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Publikationsdatum:
22. Mai 2007 (online)

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Significance

Marinomycins A-C were isolated from a marine actinomycete. They exhibit potent antibiotic activity against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium. They also display potent cytotoxicity towards a range of cancer cell lines. The synthesis depicted creates the macrocycle by an intramolecular Suzuki coupling.