Low-Temperature Cross-Coupling of Functionalized Grignard Reagents

Significance

The Kumada-Corriu cross-coupling process is very attractive since the required (het)arylmagnesium species, including polyfunctionalized ones, can be readily prepared directly by the halogen-magnesium exchange or a metallation reaction. The group of Buchwald report herein a robust protocol, allowing a very efficient coupling of polyfunctionalized arylmagnesium species at the temperatures, which tolerate a vast majority of functional groups. This method is therefore extremely attractive for the direct synthesis of functionalized biaryls starting from (het)aryl halides.