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Synfacts 2007(10): 1066-1066  
DOI: 10.1055/s-2007-969012
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Fe(salan)-Catalyzed Oxidation of Sulfides with Hydrogen Peroxide in Water

Contributor(s): Hisashi Yamamoto, Matthew B. Boxer
H. Egami, T. Katsuki*
Kyushu University, Fukuoka, Japan
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Publikationsdatum:
07. November 2007 (online)

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Significance

With the emergence and obvious importance of green chemistry, the Katsuki group has created a nice protocol for the oxidation of sulfides in water without the need for surfactants. The reaction only requires the sulfide, the catalyst (1 mol%), and 1.5 equivalents of aqueous H2O2 with water as solvent. High enantioselectivities are obtained for a large scope of aryl-alkyl and aryl-aryl sulfide substrates.